Short Bio
Dr. Xuri Li is a Professor and the Scientific Director of the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Dr. Li graduated from Shanghai Medical University, obtained her Ph.D. from Karolinska Institute in Stockholm, Sweden, and received her postdoctoral training at the Karolinska Institute and the Vesalius Research Center in Leuven University, Belgium. During 2005-2012, Dr. Li served as a Principal Investigator at the National Institutes of Health, National Eye Institute in USA. Dr. Li has published 103 scientific publications (total IF ≥ 1040) and is a referee of 23 international journals. Dr. Li is an inventor of numerous international patents and is the founder of the Asia Pacific Vascular Biology Organization (APVBO).
Major Research Interests
Our team strives to understand the processes of angiogenesis, vasculogenesis and neurogenesis in the eye in development, normal physiology and various pathologies. We hope to use the gained knowledge to explore better therapies for human diseases. Specifically, we characterize the functional properties of important angiogenic and antiangiogenic molecules using animal models, cultured cells and molecular approaches. We also utilize the developing mouse eye as a model to explore the fundamental mechanisms of angiogenesis, vasculargenesis and neurogenesis. Furthermore, we try to reveal the basic cellular and molecular mechanisms underlying our findings.
NIH Intramural Funding as a Principal Investigator
2006 US $1,770,000
2007 1Z01EY000447-01 US $1,774,036
2008 1Z01EY000447-02 US $1,523,283
2009 1ZIAEY000447-03 US $1,347,483
2010 1ZIAEY000447-04 US $1,342,304
2011 1ZIAEY000447-05 US $1,409,461
2012 1ZIAEY000447-06 US $1,047,086
FUNDING IN CHINA AS A PRINCIPAL INVESTIGATOR
2013-2017 1000-Plan Expert, Leading Expert of the Sun Yat-Sen University, Principal Investigator, 12000000 CNY
2014-2018 NSFC National Key Program, Principal Investigator, 2900000 CNY
2014-2018 Guangdong Province Leading Expert Program, Principal Investigator, 5000000 CNY
2016-2017 NSFC China-Sweden International Collaboration Program, Principal Investigator, 240000 CNY
2017-2020 NSFC grant, Principal Investigator, 540000 CNY
2018-2021 Guangzhou Science and Development Key Program, Principal Investigator, 2000000 CNY
2019-2022 Boehringer-Ingelheim innovation research grant, 3628800 CNY
REVIEWED SCIENTIFIC MANUSCRIPTS FOR:
Nature Metabolism
Nature Protocols
Journal of Experimental Medicine
Proceedings of the National Academy of Sciences USA
Blood
Circulation Research
Molecular Therapy
Biomaterials
The FASEB Journal
Cancer Letters
Gene Therapy
Oncogene
The Journal of Pathology
The American Journal of Pathology
Science Advances
Aging
PLoS ONE
Pigment Cell & Melanoma Research
Experimental Eye Research
Investigative Ophthalmology and Visual Science
British Journal of Ophthalmology
Journal of Visualized Experiments
Journal of Geriatric Cardiology
REVIEWED RESEARCH GRANT FOR:
Intercellular Interactions Study Section, Center for Scientific Review, NIH, USA
Atherosclerosis and Inflammation in the Cardiovascular Systems Study Section, Center for Scientific Review, NIH, USA
The Agency for Science, Technology and Research’s (A*STAR), Biomedical Research Council (BMRC), Singapore
Ministry of Research and Innovation, Government of Ontario, Canada
Medical Research Council, Research Councils UK
American Institute of Biological Sciences (AIBS), USA
The National Natural Science Foundation of China (NSFC)
Selected Publications
Ekstrom T.J., Cui H., Xuri Li, Ohlsson R., Promoter-specific IGF2 imprinting status and its plasticity during human liver development, Development, 121(2):309-316, 1995, PubMed
Xuri Li, Adam G., Cui H., Sandstedtedt B., Ohlsson R., Ekstrom T.J. Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting, Oncogene, 1(2):221-229, 1995, PubMed
Xuri Li, Nong Z., Ekström C., Larsson E., Nordlinder H., Hofmann W. J, Trautwein C., Odenthal M., Dienes H.P., Ekstrom T. J. and Schirmacher P. Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma, Cancer Res, 57(10):2048-2054, 1997, PubMed
Xuri Li, Ponten A., Aase K., Linda K., Abramsson A., Uutela M., Backman G., Hellstrom M., Bostrom H., Li H., Betsholtz C., Heldin C. H., Alitalo K., Ostman A. & Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF-a receptor, Nat Cell Biol, 2(5):302-309, 2000 PubMed
(Featured News & Views: A new member of an old family, Nat Cell Biol, 2(5): E78-79, 2000 PubMed)
Bergsten, E., Uutela, M., Xuri Li, Pietras, K., Ostman, A., Heldin, C. H., Alitalo, K., Eriksson, U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-Receptor, Nat Cell Biol, 3(5):515-516, 2001, PubMed
Hellstrom, M., Gerhardt, H., Kalen, M., Xuri Li, Eriksson, U., Wolburg, H., Betsholtz, C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis, J Cell Biol, 153(3):543-554, 2001, PubMed
Uutela, M., Lauren, J., Bergsten, E., Xuri Li, Horelli-Kuitunen, N., Eriksson, U., Alitalo, K., Chromosomal location, exon structure, and vascular expression patterns of the human PDGF-C and PDGF-C genes, Circulation, 103(18):2242-2247, 2001, PubMed
Aase, K., Von Euler, G., Xuri Li, Ponten, A., Thoren, P., Cao, Y., Olofsson, B., Gebre-Medhin, S., Pekny, M., Alitalo, K., Betsholtz C., Eriksson, U. VEGF-B deficient mice display an atrial conduction defect, Circulation, 104(3):358-364, 2001, PubMed
Eitner F., Ostendorf T., Van Roeyen C., Kitahara M., Xuri Li, Aase K., Groene H-J., Eriksson U., Floege J. Expression of a Novel PDGF Isoform, PDGF-C, in Normal and Diseased Rat Kidney, J Am Soc Nephrol, 13(4):910-917, 2002, PubMed
Cao, R., Brakenhielm, E., Xuri Li, Pietras K., Widenfalk J., Ostman A., Eriksson, U., Cao, Y. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors, FASEB J, 16(12):1575-1583, 2002, PubMed
Li, H., Karlsson L., Xuri Li, Eriksson, U. PDGF-D is a potent transforming and angiogenic factor, Oncogene, 22(10):1501-1510, 2003, PubMed
Ponten A., Xuri Li, Aase K., Thoren P., Sjoblom T., Ostman A. and Eriksson U., Overexpression of PDGF-C in mouse heart induces cardiac fibrosis, hypertrophy and dilated cardiomyopathy, Am J Pathol, 163(2):673-682, 2003, PubMed
Fredriksson, L., Li, H., Fieber, C., Xuri Li and Eriksson U., Tissue plasminogen activator is a potent activator of PDGF-CC, EMBO, 23(19):3793-3802, 2004, PubMed
Xuri Li, Tjwa, M., Moons, L., Fons, P., Noel, A., Ny, A., Zhou, J. M., Lennartsson, J., Li, H., Luttun, A., Ponten, A., Devy, L., Bouche, A., Oh, H., Manderveld, A., Blacher, S., Communi, D., Savi, P., Bono, F., Dewerchin, M., Foidart, J. M., Autiero, M., Herbert, J. M., Collen, D., Heldin, C. H., Eriksson, U., Carmeliet, P., Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors, J Clin Invest, 115(1):118-127, 2005, PubMed
JCI Article In The News: PDGF-CC, the best thing ever since sliced bread? J Clin Invest, 115(1), 2005 website
Featured News: Platelet-derived growth factor CC--a clinically useful angiogenic factor at last?, N Engl J Med, 352(17): 1815-1816, 2005 website
Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G. H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C. H., Xuri Li*, VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats, J Clin Invest, 118(3):913–923, 2008, PubMed
Xuri Li, Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Diez Juan, T., Sievers, R. E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J. M., Springer, M. L., von Degenfeld, G., Dewerchin, M., Blau, H. M., Alitalo, K., Eriksson, U., Carmeliet, P., Moons, L., Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium, Arterioscler Thromb Vasc Biol, 28(9):1614-1620, 29, 2008, PubMed
Anderberg, C., Li, H., Fredriksson, L., Andrae, J., Betsholtz, C., Xuri Li, Eriksson, U., Pietras, K., Paracrine signaling by PDGF-CC promotes tumor growth by recruitment of cancer-associated fibroblasts, Cancer Res, 69(1):369-378, 2009, PubMed
Gavard, J., Hou, X., Qu, Y., Masedunskas, A., Weigert, R., Xuri Li, Gutkind, JS., A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability, Mol Cell Biol, 29(9):2469-2480, 2009, PubMed
Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch, A. W., Scotney, P., Lee, C., Arjunan, P., Dong, L., Kumar, A., Rissanen, T. T., Wang, B., Nagai, N., Fons, P., Fariss, R., Zhang, Y., Wawrousek, E., Tansey, G., Raber, J., Fong, G. H., Ding, H., Greenberg, D. A., Becker, K. G., Herbert, J. M., Nash, A., Yla-Herttuala, S., Watts, R. J., Xuri Li*, VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis, Proc Natl Acad Sci USA, 106(15):6152-6157, 2009, PubMed
Tang, Z., Arjunan, P., Lee, C., Li, Y., Kumar, A., Hou, X., Wang, B., Wardega, P., Zhang, F., Dong, L., Zhang, Y., Zhang, S. Z., Ding, H., Fariss, R. N., Becker, K. G., Lennartsson, J., Nagai, N., Cao, Y., Xuri Li*, Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation, J Exp Med, 207(4):867-880, 2010, PubMed
Kumar, A., Hou, X., Lee, C., Li, Y., Maminishkis, A., Tang, Z., Zhang, F., Langer, H. F., Arjunan, P., Dong, L., Wu, Z., Zhu, L. Y., Wang, L., Min, W., Colosi, P., Chavakis, T., Xuri Li*, PDGF-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase 3 beta (GSK3{beta}) phosphorylation, J Biol Chem, 285(20):15500-15510, 2010, PubMed
Cover image for J Biol Chem, 285(20), 2010 website
Sakurai, A., Gavard, J., Annas-Linhares, Y., Basile, J. R., Amornphimoltham, P., Palmby, T. R., Yagi, H., Zhang, F., Randazzo, P. A., Xuri Li, Weigert, R., Gutkind, J. S., Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras, Mol Cell Biol, 30(12):3086-98, 2010, PubMed
Hou, X., Kumar, A., Lee, C., Wang, B., Arjunan, P., Dong, L., Maminishkis, A., Tang, T., Li, Y., Zhang, F., Zhang, S-Z., Wardega, P., Chakrabarty, S., Liu, B., Wu, Z., Colosi, P., Fariss, R. N., Lennartsson, J., Nussenblatt, R., Gutkind, J. S., Cao, Y., Xuri Li*, PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets, Proc Natl Acad Sci USA, 107(27):12216-12221, 2010, PubMed
Narazaki, M., Segarra, M., Hou, X., Tanaka, T., Xuri Li, Tosato, G., Oligo-guanosinenucleotide induces Neuropilin-1 internalization in endothelial cells and inhibits angiogenesis, Blood, 116(16):3099-3107, 2010, PubMed
Langer, H. L., Chung, K-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., Xuri Li, Economopoulou, M., Rafail, S., Lambris, J. D., Chavakis, T., Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis, Blood, 116(22):4395-4403, 2010, PubMed
Xuri Li*, VEGF-B: a thing of beauty, Cell Res, 20(7): 741-744, 2010, PubMed
Langer, H. F., Choi, E. Y., Zhou, H., Schleicher, R., Chung, K. J., Tang, Z., Gobel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C., Bhatia, S., Kruhlak, M. J., Rose, J. W., Burns, J. B., Hill, K. E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K. G., Wang, Y., Simon, D. I., Nieswandt, B., Lambris, J. D., Xuri Li, Meuth, S. G., Kubes, P., Chavakis, T., Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis, 110(9):1202-1210, Circ Res, 2012, PubMed
Zhang, F., Li, Y., Tang, Z., Kumar, A., Lee, C., Zhang, L., Zhu, C., Ameln, A. K., Wang, B., Gao, Z., Zhang, S., Langer, H., Hou, X., Jensen, L., Ma, W., Wong, W., Chavakis, T., Liu, Y., Cao, Y., Xuri Li*, Proliferative and survival effects of PUMA promotes angiogenesis, 2(5):1272-1285, Cell Reports, 2012, PubMed
Biomedical Picture of the Day: Double Agent PUMA, Website
Segarra, M., Ohnuki, H., Maric, D., Salvucci, O., Hou, X., Xuri Li, and Tosato, G., Semaphorin 6A regulates angiogenesis by modulating VEGF signaling, Blood, 120(19):4104-4115, 2012, PubMed
Xuri Li*, Kumar, A., Zhang, F., Lee, C., Tang, Z., Complicated life, complicated VEGF-B, Trends Mol Med, 18(2):119–127, 2012, PubMed
Cover image for Trends in Molecular Medicine, 18(2), 2012, Website
Hosaka, K., Yang, Y., Seki, T., Nakamura, M., Andersson, P., Rouhi, P., Yang, X., Jensen, L., Lim, S., Feng, N., Xue, Y., Xuri Li, Larsson, O., Ohhashi, T., Cao, Y., Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis, Nat Commun, 4:2129, 2013, PubMed
Dong, M., Yang, X., Lim, S., Cao, Z., Honek, J., Lu, H., Zhang, C., Seki, T., Hosaka, K., Wahlberg, E., Yang, J., Zhang, L., Lanne, T., Sun, B., Xuri Li, Liu, Y., Zhang, Y., Cao, Y., Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent Lipolysis, Cell Metab, 18(1):118-129. 2013, PubMed
Lee, C., Zhang, F., Tang, Z., Liu, Y., Xuri Li*, PDGF-C: a new performer in the neurovascular interplay, Trends Mol Med, 19(8):474-86, 2013, PubMed
Huang, Y., Hoffman, C., Rajappa, P., Kim, J. H., Hu, W., Huse, J. T., Tang, Z., Xuri Li, Weksler, B., Bromberg, J., Lyden, D., Greenfield, J. P., Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier, Cancer Res, 74(4):1011-1021, 2014, PubMed
He, C., Zhao, C., Kumar, A., Lee, C., Chen, M., Huang, L., Wang, J., Ren, X., Jiang, Y., Chen, W., Wang, B., Gao, Z., Zhong, Z., Huang, Z., Zhang, F., Huang, B., Ding, H., Ju, R., Tang, Z., Liu, Y., Cao, Y., Xuri Li*., Liu, X*., Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration, Proc Natl Acad Sci U S A, 111(41):14806-11, 2014, PubMed
Salvucci, O., Ohnuki, H., Maric, D., Hou, X., Xuri Li, Yoon, S. O., Segarra, M., Eberhart, C. G., Acker-Palmer, A., Tosato, G., EphrinB2 controls vessel pruning through STAT1-JNK3 signalling, Nat Commun, 6:6576, 2015, PubMed
R. I. Schleicher, F. Reichenbach, P. Kraft, A. Kumar, M. Leskan, F. Todt, K. Goebel, T. Geisler, A. Bauer, S. Wesselborg, L. O’Reilly, S. G. Meuth, K. Schulze-Osthoff, M. Gawaz, Xuri Li, C. Kleinschnitz, F. Edlich, H. Langer, Platelets induce apoptosis via membrane-bound FasL, Blood, 126(12):1483-1493, 2015, PubMed
L D. Jensena, M Nakamuraa, L Bräutigamc, Xuri Li, Y Liu, N J. Samanie, and Y Cao, VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish, Proc Natl Acad Sci U S A, 12(44):E5944-53, 2015, PubMed
Lin, H., Ouyang, H., Zhu, J., Huang, S., Liu, Z., Chen, S., Cao, G., Li, G., Signer, R. A., Xu, Y., Chung, C., Zhang, Y., Lin, D., Patel, S., Wu, F., Cai, H., Hou, J., Wen, C., Jafari, M., Liu, X., Luo, L., Qiu, A., Hou, R., Chen, B., Chen, J., Granet, D., Heichel, C., Shang, F., Xuri Li, Krawczyk, M., Skowronska-Krawczyk, D., Wang, Y., Shi, W., Chen, D., Zhong, Z., Zhong, S., Zhang, L., Morrison, S. J., Maas, R. L., Zhang, K., Liu, Y., Lens regeneration using endogenous stem cells with gain of visual function, Nature, 351(7594):323-328, 2016, PubMed
Seki, T., Hosaka, K., Lim, S., Fischer, C., Honek, J., Yang, Y., Andersson, P., Nakamura, M., Naslund, E., Yla-Herttuala, S., Sun, M., Iwamoto, H., Xuri Li, Liu, Y., Samani, N. J., Cao, Y., Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat, Nat Commun, 7:12152, 2016, PubMed
Jiang, Y., Lin, X., Tang, Z., Lee, C., Tian, G., Du, Y., Yin, X., Ren, X., Huang, L., Ye, Z., Chen, W., Zhang, F., Mi, J., Gao, Z., Wang, S., Chen, Q., Xing, L., B. Wang, Y. Cao, W. C. Sessa, R. Ju*, Y. Liu*, Xuri Li*, Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK, Proc Natl Acad Sci U S A, 114(40): 10737-10742, 2017, PubMed
Weisi Lu, Xuri Li*, Vascular stem/progenitor cells: functions and signaling pathways, Cell Mol Life Sci, 75(5):859-869, 2017, PubMed
Xuri Li*, Carmeliet, P.*, Targeting angiogenic metabolism in disease, Science, 359(6382):1335-1336, 2018, PubMed
Chunsik Lee, Xuri Li*, Platelet-derived growth factor-C and -D in the cardiovascular system and diseases, Molecular Aspects of Medicine, 62:12-21, 2018, PubMed
Weisi Lu, Xuri Li*, PDGFs and their receptors in vascular stem/progenitor cells: Functions and therapeutic potential in retinal vasculopathy, Molecular Aspects of Medicine, 62:22-32, 2018, PubMed
Anil Kumar, Xuri Li*, PDGF-C and PDGF-D in ocular diseases, Molecular Aspects of Medicine, 62:33-43, 2018, PubMed
S. Vandekeere, C. Dubois, J. Kalucka, M. R. Sullivan, M. Gar-cía-Caballero, J. Goveia, R. Chen, F. F. Diehl, Libat Bar-Lev, J. Souffreau, A. Pircher, S. Kumar, S. Vinckier, Y. Hirabayashi, S-g. Furuya, L. Schoonjans, G. Eelen, B. Ghesquière, E. Keshet, Xuri Li*, M. G. V. Heiden, M. Dewerchin*, & P. Carmeliet*, Serine synthesis via PHGDH is essential for heme production in endothelial cells, Cell Metabolism, 28(4):573-587, 2018, PubMed
Bruning, U., Morales-Rodriguez, F., Kalucka, J.Goveia, J., Taverna, F., Queiroz, K. C. S., Dubois, C., Cantelmo, A. R., Chen, R., Loroch, S., Timmerman, E., Caixeta, V.Bloch, K., Conradi, L. C., Treps, L., Staes, A., Gevaert, K., Tee, A., Dewerchin, M., , Semenkovich, C. F., Impens, F., Schilling, B., Verdin, E., Swinnen, J. V., Meier, J. L., Kulkarni, R. A., Sickmann, A., Ghesquiere, B., Schoonjans, L., Xuri Li*, Mazzone, M., Carmeliet, P.*, Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation, Cell Metabolism, 28(6):866-880, 2018, PubMed
Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Bruning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., Vriens, K., Pilz, G. A., Chen, R., Cubbon, R., Thienpont, B., Cruys, B., Wong, B. W., Ghesquiere, B., Dewerchin, M., De Bock, K., Sagaert, X., Jessberger, S., Jones, E. A. V., Gallez, B., Lambrechts, D., Mazzone, M., Eelen, G., Xuri Li*, Fendt, S. M., Carmeliet, P.*, Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis, Cell Metabolism, 28(6):881-894, 2018, PubMed
Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., Chen, R., Huang, H., Vandekeere, S., Kalucka, J., Lange, C., Morales-Rodriguez, F., Cruys, B., Treps, L., Ramer, L., Vinckier, S., Brepoels, K., Wyns, S., Souffreau, J., Schoonjans, L., Lamers, W. H., Wu, Y., Haustraete, J., Hofkens, J., Liekens, S., Cubbon, R., Ghesquiere, B., Dewerchin, M., Gervasio, F. L., Xuri Li*, van Buul, J. D., Wu, X., & Carmeliet, P.*, Role of glutamine synthetase in angiogenesis beyond glutamine synthesis, Nature, 561(7721):63-69, 2018, PubMed
Arjunan, P., Lin, X., Tang, Z., Du, Y., Kumar, A., Liu, L., Yin, X., Huang, L., Chen, W., Chen, Q., Ye, Z., Wang, S., Kuang, H., Zhou, L., Xu, K., Chen, X., Zeng, H., Lu, W., Cao, Y., Liu, Y., Zhao, C.*, Xuri Li*, VEGF-B is a potent antioxidant, Proc Natl Acad Sci U S A, 115(41): 10351-10356, 2018, PubMed
Metabolic pathways fueling the endothelial cell drive, Xuri Li*, Anil Kumar, & Peter Carmeliet*, Annual Reviews of Physiology, 81:483-503, 2019, PubMed
EndoDB: a database of endothelial cell transcriptomics data, Khan, S., Taverna, F., Rohlenova, K., Treps, L., Geldhof, V., de Rooij, L., Sokol, L., Pircher, A., Conradi, L. C., Kalucka, J., Schoonjans, L., Eelen, G., Dewerchin, M., Karakach, T., Xuri Li*, Goveia, J., Carmeliet, P.*, Nucleic Acids Res, 47(D1): D736-D744, 2019, PubMed
Hallmarks of Endothelial Cell Metabolism in Health and Disease, Cell Metabolism, Xuri Li*, Sun, X., Carmeliet, P.*, 30:414-433, 2019, PubMed
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates, Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L. C., Pircher, A., Geldhof, V., de Rooij, Lpmh, Kalucka, J., Sokol, L., Garcia-Caballero, M., Zheng, Y., Qian, J., Teuwen, L. A., Khan, S., Boeckx, B., Wauters, E., Decaluwe, H., De Leyn, P., Vansteenkiste, J., Weynand, B., Sagaert, X., Verbeken, E., Wolthuis, A., Topal, B., Everaert, W., Bohnenberger, H., Emmert, A., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Impens, F., Lagani, V., Vinckier, S., Mazzone, M., Schoonjans, L., Dewerchin, M., Eelen, G., Karakach, T. K., Yang, H., Wang, J., Bolund, L., Lin, L., Thienpont, B., Xuri Li*, Lambrechts, D., Luo, Y., Carmeliet, P.*, Cancer Cell, 37(1): 21-36 e13, Jan., 2020, PubMed
Single-Cell Transcriptome Atlas of Murine Endothelial Cells, Kalucka, J., de Rooij, Lpmh, Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L. A., Veys, K., Garcı´a-Caballero, M., Khan, S., Geldhof, V., Sokol, L., Chen, R., Treps, L., Borri, M., de Zeeuw, P., Dubois,C., Karakach, T. K., Falkenberg, K. D., Parys, M., Yin, X., Vinckier, S., Du, Y., Fenton, R. A., Schoonjans, L., Dewerchin, M., Eelen, G., Thienpont, B., Lin, L., Bolund, L., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Cell, 180(4): 764-779 e20, 2020, PubMed
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis, Rohlenova, K., Goveia, J., Garcia-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, Lpmh, Zheng, Y., Lin, L., Sokol, L., Teuwen, L. A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L. C., Khan, S., Stegen, S., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Vinckier, S., Van Bergen, T., Ectors, N., De Haes, P., Wang, J., Bolund, L., Schoonjans, L., Karakach, T. K., Yang, H., Carmeliet, G., Liu, Y., Thienpont, B., Dewerchin, M., Eelen, G., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Cell Metab, 31(4): 862-877 e14, April, 2020, PubMed
Eelen, G., Treps, L., Xuri Li, Carmeliet, P., Basic and Therapeutic Aspects of Angiogenesis Updated." Circ Res, 127(2): 310-329, 2020, PubMed
Weisi Lu*, Yunling Xie1, Binjie Huang1, Tenghui Ma, Huaiming Wang, Boxion Deng, Shaomin Zou, Wencong Wang, Qin Tang, Ziqing Yang, Xuri Li*, Lei Wang, Lekun Fang*, Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy, Sci Transl Med, 13, eabc2344, 24 February 2021, PubMed
S. J. Dumas, E. Meta, M. Borri, Y. Luo, Xuri Li*, T. J. Rabelink*, P. Carmeliet*, Phenotypic diversity and metabolic specialization of renal endothelial cells, Nature Reviews Nephrology, March 25, 2021, PubMed
Book Chapters
Eriksson, U., Li, X. Chapter: Vascular Endothelial Growth Factor B (VEGF-B),Encyclopedia of Hormones, edited by Henry, HL & Norman, AW, Elsevier Science, Academic press, 2003
Li, X.*, Kumar, A., Lee, C., Tang, Z., Li, Y., Arjunan, P., Hou, X., Zhang, F., Can VEGF-B be used to treat neurodegenerative diseases? Neurodegenerative Diseases - Book 1, ISBN 979-953-307-041-3, InTech, Open Access Publisher, 2011
Ju, R., Lee, C., Lu, W., Li, X*., Fibroblast Growth Factors: Biology and Clinical Application, Growth Factors in the Eye, ISBN: 978-981-3143-36-4, World Scientific, 2017